Young type 1 diabetes mellitus (T1DM) patient with glucose-6-phosphate dehydrogenase deficiency occurring hemolysis: A case report
نویسندگان
چکیده
Hemolysis during type 1 diabetes mellitus treatment in patients with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency has been reported, but the underlying pathogenesis is not fully clarified. In this report, we described a girl in whom hemolysis occurred after Diabetic Ketoacidosis (DKA) treatment. Determination of G6PD activity and gene analysis confirmed the diagnosis of G6PD deficiency. We suppose that reducing of G6PD activity by hyperglycemia and decreased source of glucose in the pentose phosphate pathway because of decrease glucose levels may be the mechanism of hemolysis during DKA treatment.
منابع مشابه
Intravascular Hemolysis Due to Glucose‐6‐Phosphate Dehydrogenase Deficiency in a Patient with Aluminium Phosphide Poisoning
Aluminium Phosphide poisoning and glucose‐6‐phosphate dehydrogenase deficiency are two commonly seen clinical presentations in Iran. However, hemolysis associated with Aluminium Phosphide poisoning is very rare. We report a case of concurrent Aluminium Phosphide poisoning and glucose‐6‐phosphate dehydrogenase deficiency in a 24 year old man presenting with intravascular hemolysis. Key words...
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AIM Epidemiological data suggest that glucose-6-phosphate dehydrogenase (G6PD) deficiency may be a risk factor for diabetes. Also, the occurrence of haemolysis in the context of diabetes crises has been reported in patients with G6PD deficiency. A unifying hypothesis could explain these associations. METHODS We report two patients in whom haemolytic crises occurred soon after acute diabetes d...
متن کاملIntravascular haemolysis due to glucose-6-phosphate dehydrogenase deficiency in a patient with aluminium phosphide poisoning.
Aluminium Phosphide poisoning and glucose-6-phosphate dehydrogenase deficiency are two commonly seen clinical presentations in Iran. However, hemolysis associated with Aluminium Phosphide poisoning is very rare. We report a case of concurrent Aluminium Phosphide poisoning and glucose-6-phosphate dehydrogenase deficiency in a 24 year old man presenting with intravascular hemolysis.
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INTRODUCTION Previously undiagnosed glucose-6-phosphate dehydrogenase (G6PD) deficiency can be unmasked by a diabetic crisis and both can be associated with rhabdomyolysis. The relationship between diabetes and G6PD deficiency is discussed and the possible triggers for haemolysis as outlined in this case report. The incidence of G6PD deficiency is 10% in African-American males and up to 35% in ...
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